Curriculum Vitae Klaus Klaushofer

Personalia
Name: Klaus Klaushofer
Academic title: M.D., Prof.
Date of birth: August 7th, 1950, Tamsweg
Citizenship: Austrian
Marital status: married
Address: 1st Medical Department, Hanusch Hospital, Heinrich Collin Str. 30, A-1140 Vienna
Website: www.wgkk.at, www.osteologie.at
Email: klaus.klaushofer@wgkk.at, klaus.klaushofer@osteologie.at
Telephone: +43 (0)1 910 21-84011 (Hanusch Hospital), +43 (0)1 910 21-86921 (Ludwig Boltzmann Institute of Osteology)

Education
1960 – 1968: Höhere Internatsschule des Bundes, Saalfelden
1968 – 1974: University of Vienna, Medical School
1974 – 1980: Internal Medical Residency
1993/94: Management Course for Managers in Medical Professions

Professional career
Since 2011: Head of 1st Medical Department, Hanusch Hospital (Osteology and Rheumatology, Nephrology, Gastroenterology and Hepatology, Pulmonology, Diabetology, Endocrinology and Metabolism, Geriatrics and Rehabilitation, Internal Emergency Unit)
2010: Head of 4th and 1st Medical Department, Hanusch Hospital
2001 - 2010: Head of 4th Medical Department, Hanusch Hospital
Since 2001: Medical Director, Hanusch Hospital
Since 2000: Consultant Physician of the Main Association of Austrian Social Insurance Institutions
1995: Professor, University of Vienna, Medical School
Since 1991: Scientific and Administrative Head, Ludwig Boltzmann Institute of Osteology
1989: Associate Professor, University of Vienna, Medical School
1987 - 1991: Scientific Secretary, Ludwig Boltzmann Research Unit for Clinical and Experimental Osteology
1982 - 2001: Senior Physician and Deputy Head, 4th Medical Deptartment, Hanusch Hospital
1982 - 2010: 4th Medical Department, Hanusch Hospital Specialisation: Geriatrics and Rehabilitation, Endocrinology, Osteology, Rheumatology, Pulmonology, Internal Emergency Medicine)
1980: Specialist in Internal Medicine (additional degrees in Rheumatology, Endocrinology and Metabolism)
1975 - 1982: 1st Medical Department, Hanusch Hospital
1975: Postdoctoral Research Associate, Department of Anatomy, Medical School, Hannover, Germany
1973/74: Research Assistent, Institute for Micromorphology and Electronmicroscopy, University of Vienna, Medical School

Main research areas
“Translational research from basic science to clinical application”
Structure/function relationship of bone material in health and disease
Organic matrix, mineralization, mechanical characterization
Bone cell regulation by cytokines and hormones
Cell/matrix interactions
Pathophysiology, Differentialdiagnosis and Treatment of Bone Diseases

Scientific publications (per 30 May, 2011)
Publications in peer-reviewed international journals: 319
Proceedings papers (> 2 pages): 90
Book sections: 18
Short abstracts/proceedings papers (≤ 2 pages): 492
Invited scientific lectures: 162
H-Index: 35
Member of the ASBMR-Task Force for Atypical Subtrochanteric and Diaphyseal Femoral Fractures (J Bone Miner Res. 2010 Nov;25(11):2267-94)
Chair of the Expert Group of Medication & Rationality (www.arzneiundvernunft.info)

Selected scientific evaluation activities
Reviewer for international journals (i.e. JBMR, Calcified Tissue International, Bone, Osteoporosis International, Transplant International, American Journal of Medical Genetics, Journal of Clinical Endocrinology and Metabolism, Nature Reviews Endocrinology)
Reviewer for National Science Agencies (Medical Research Scotland, Wellcome Trust United Kingdom, Biotechnology and Biological Sciences Research Council United Kingdom, Research into Ageing, Help the Aged, London, Israel Science Foundation)
Chair of the International Jury of the Research Prize of the Austrian Society for Bone and Mineral Research
Member of the Advisory Committee of Theodor Körner Fonds
Member of the Oberster Sanitätsrat (Austrian Advisory Committee for Public Health Issues)
Member of the Drug Evaluation Committee of the Main Association of Austrian Social Insurance Institutions

Selected conference activities
2011 Chair of the Organizing Committee of the International Conference on Progress in Bone and Mineral Research, Vienna 1998, 2000, 2003, 2006, 2012
2009: Member of the Scientific Programme Committee and Local Organizing Committee of the 36th European Symposium on Calcified Tissues, Vienna
2000: Member of the International Programme Committee of the 27th European Symposium on Calcified Tissues, Tampere, Finland
1999: Member of the Scientific Programme Committee of the 21st Annual Meeting of the American Society for Bone and Mineral Research, St. Louis, Missouri, USA
1991: Member of the Organizing Committee and the Scientific Programme Committee of the 22nd European Symposium on Calcified Tissues, Vienna; Organizer of the Post-Symposium-Workshop "Functional Regulation of Bone Cell Biology by Mechanical Factors" and Guest Editor of the Supplement of the Journal of Bone and Mineral Research

Selected memberships
AuSBMR, ECTS, IBMS, ASBMR, Endocrine Society, OEGIM (Austrian Society for Internal Medicine), OEGR (Austrian Society for Rheumatology and Rehabilitation), OEGES (Austrian Society for Endocrinology and Metabolism), Gesellschaft der Ärzte in Wien

Awards
2009: DAdorW Award for the scientific work group having the most excellent scientific publications within the previous year in the German-speaking area

2007: Copp-Award of the German Society for Osteology for the publication: „Peterlik H, Roschger P, Klaushofer K, Fratzl P 2006 From brittle to ductile fracture of bone. Nat Mater 5(1):52-5.“

2000: Byk-TOSSE-Osteology Award for the publication: „Roschger P, Fratzl P, Eschberger J, Klaushofer K 1998 Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23(4):319-26.” and “P. Roschger, P. Fratzl, J. Eschberger, K. Klaushofer 1999 Letters to the Editor. Bone 24(6):619-21.“

1997: Copp-Award of the German Society for Osteology for the publication:“ Fratzl P, Paris O, Klaushofer K, Landis WJ 1996 Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering. J Clin Invest 97(2):396-402.”

1994: Austrian State Award of the Austrian Federal Ministry of Science and Research for Basic Research in Rheumatology for the publication: „Fratzl P, Roschger P, Eschberger J, Abendroth B, Klaushofer K 1994 Abnormal bone mineralization after fluoride treatment in osteoporosis. A small-angle x-ray scattering study. J Bone Min Res 9(10):1541-49.”

1989: Carl von Rokitansky Award of the Austrian Society for Pathology for the publication: “Klaushofer K, Hörandner H, Hoffmann O, Czerwenka E, König U, Koller K, Peterlik M 1989 Interferon gamma and calcitonin induce differential changes in cellular kinetics and morphology of osteoclasts in cultured neonatal mouse calvaria. J Bone Min Res 4(4):585-606.“

1987: Autrotransplant-Award of the Austrian Society for Transplantation, Transfusion and Genetics "Austro-transplant" for the publication: „Klaushofer K, Hoffmann O, Stewart P J, Czerwenka E, Koller K, Peterlik M, Stern PH 1987 Cyclosporine A inhibits bone resorption in cultured neonatal mouse calvaria. J Pharmacol Exp Therap 243(2):584-90.“

1986: Promotion-Award of the First Austrian Savings Bank for the publication: “Niederle B, Roka R, Kovarik J, Klaushofer K, Schernthaner G, Fritsch A 1986 Klinische Erfahrungen nach operativer Therapie der asymptoma-tischen, oligosymptomatischen und symptomatischen Nebenschilddrüsen-überfunktion. Klin. Wochenschr 64:917-23.”

11. Most important publications of the academic career (per 30 May, 2011)

1. Roschger P, Paschalis EP, Fratzl P, Klaushofer K 2008 Bone mineralization density distribution in health and disease. Bone 42(3):456-66.
2. Peterlik H, Roschger P, Klaushofer K, Fratzl P 2006 From brittle to ductile fracture of bone. Nat Mater 5(1):52-5. Epub 2005 Dec 11.
3. Klaushofer K, Varga F, Glantschnig H, Fratzl-Zelman N, Czerwenka E, Leis HJ, Koller K, Peterlik M 1995 The regulatory role of thyroid-hormones in bone cell-growth and differentiation. J Nutr 125(7 Suppl):1996S-2003S.
4. Roschger P, Rinnerthaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K 2001 Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29(2):185-91.
5. Misof BM, Roschger P, Cosman F, Kurland ES, Tesch W, Messmer P, Dempster DW, Nieves J, Shane E, Fratzl P, Klaushofer K, Bilezikian J, Lindsay R 2003 Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88(3):1150-56.
6. Fratzl P, Roschger P, Eschberger J, Abendroth B, Klaushofer K 1994 Abnormal bone mineralization after fluoride treatment in osteoporosis - a small-angle x-ray-scattering study. J Bone Miner Res 9(10):1541-49.
7. Roschger P, Manjubala I, Zoeger N, Meirer F, Simon R, Li C, Fratzl-Zelman N, Misof BM, Paschalis EP, Streli C, Fratzl P, Klaushofer K 2010 Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment. J Bone Miner Res. 25(4):891-900.
8. Fratzl P, Paris O, Klaushofer K, Landis WJ 1996 Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering. J Clin Invest 97(2):396-402.
9. Klaushofer K, Hoffmann O, Stewart PJ, Czerwenka E, Koller K, Peterlik M, Stern PH 1987 Cyclosporine-A inhibits bone-resorption in cultured neonatal mouse calvaria. J Pharmacol Exp Ther 243(2):584-90.
10. Fratzl P, Groschner M, Vogl G, Plenk H, Eschberger J, Fratzl-Zelman N, Koller K, Klaushofer K 1992 Mineral crystals in calcified tissues - a comparative study by SAXS. J Bone and Miner Res 7(3):329-34.
11. Thaler R, Agsten M, Spitzer S, Paschalis EP, Karlic H, Klaushofer K, Varga F 2011 Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation. J Biol Chem. 18;286(7):5578-88. Epub 2010 Dec 9.

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